Single-nucleus profiling of the adult human olfactory epithelium reveals that olfactory sensory neuron development shares transcriptional and regulatory programs with cortical neurogenesis, supporting its use as an accessible model for studying neurodevelopmental dysfunction in psychiatric disorders.
Taurine, a close analogue of tramiprosate, prevents and partially reverses ApoE4 aggregation and shifts ApoE4-associated molecular and cellular phenotypes toward ApoE3-like patterns, suggesting therapeutic potential for ApoE4-driven neurodegenerative risk.
In ventral midbrain dopaminergic neurons from schizophrenia donors, cell type-specific transcriptomic and chromatin-domain dysregulation selectively affects downregulated risk-enriched synaptic and connectivity genes, including complex susceptibility loci such as FOXP1, MAPK10, PCM1, and NRXN1.
The study uses Million Veteran Program genomic–EHR data to reveal more than 100 additional schizophrenia risk loci and ancestry-independent associations in African-ancestry populations, refining signals to convergent neurobiological genes and substantially broadening the global relevance of schizophrenia genetics.
The neuronal chromatin landscape in brains from individuals with schizophrenia is linked to early fetal development. This study maps chromatin accessibility in neurons and glia in schizophrenia, revealing fetal-like regulatory patterns in adult neurons enriched for genetic risk variants, linking early brain development to schizophrenia pathogenesis.
We analyzed 1,393 chromatin accessibility profiles from two cortical regions of 469 individuals with and without serious mental illness to characterize sex-specific regulatory mechanisms. Our findings revealed distinct enhancer–promoter interactions, cis- and trans-regulatory domains, and X-chromosome inactivation–related pathways that collectively illuminate sex-dependent epigenomic architecture and its relevance to schizophrenia.
Here the authors provide a comprehensive transcriptomic dataset of human primary microglia for Alzheimer’s disease and healthy aging. They identify dysregulation of immune-related microglial functions as a hallmark of disease.
Cell-type-specific profiling of the human orbitofrontal cortex in major depressive disorder reveals unexpected glial dysregulation, identifying the astrocytic regulator ZBTB7A as a key driver of stress-related behavioral and molecular changes, thereby implicating astrocytes in MDD-linked OFC dysfunction.
We present a rigorously curated, population-scale multi-omics dataset of over 6.3 million single-nucleus transcriptomes from 1,494 human prefrontal cortex samples—including diverse neurodegenerative and psychiatric diagnoses with rich phenotypic data and comorbidities—publicly available to advance research into shared mechanisms across major brain disorders.
Simultaneous profiling of RNA and chromatin accessibility in single nuclei isolated from human postnatal brain regions from infancy to late adulthood identifies key cellular regulators and nominates target genes and mechanisms for brain-related diseases and disorders.